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High cholesterol has long got a bad rap to challenge bad heart health -But a new study suggests that a low -carbohydrate ketogenic diet may not be associated with cardiovascular disease.
A study, conducted by the Lundquist Biomedical Innovation Institute at the Harbor-Ucla Medical Center in collaboration with researchers from several institutes, estimated 100 participants after A Long -term keto diet which developed elevated LDL cholesterol levels (known as “bad” guy).
Apart from elevated cholesterol, all participants were “metabolic healthy” and followed a key diet for five years, according to a press release on April 7th.
The risk of heart disease is higher for women who have these unhealthy lifestyles
All qualified as LMHR (Lean Mass Hyper-Responder), which indicates people who adopt a Nutrition limited by carbohydrates And experience a significant increase in cholesterol.
High cholesterol has long received a bad rap due to the cause of poor heart health-a new research suggests that the low-carbohydrate ketogenic diet may not be associated with cardiovascular disease. (East)
Using advanced heart images, researchers have found that traditional cholesterol markers (APOB and LDL-C) are not associated with plaque changes in cardiac arteries or with underlying heart disease over a one-year period.
Instead, the existing plaque level seemed to be a better predictor of the future plaque accumulation.
“This population of people – metabolic healthy with elevated LDL because it is in ketosis – is not automatically at increased heart risk just because their LDL is elevated,” said Bret Scher, MD, medical director of Baszucki Group, who provided the study by the Fox News Digital.
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“Therefore, we should probably move from LDL and APOB and according to the vascular recording with CAC or CTA for better risk prediction and information about how or if we treat someone’s heart factors,” added the California doctor.
Studies findings were published in The American of the American College of Cardiology: Advances.
Using advanced heart images, researchers have found that traditional cholesterol markers (APOB and LDL-C) are not associated with plaque changes in cardiac arteries or with underlying heart disease over a one-year period. (East)
Previous studies have also shown that people who qualify as LMHR have a similar level of coronary plaque to otherwise comparable groups that have normal LDL levels, “emphasizing that an increase in LDL caused by ketogenic diet cannot indicate a higher risk of coronary plaque,” the researcher said.
Dr. Nick Norwitz, a study leader and an independent researcher at the University of Oxford, noted that this is the first study to isolate a very high LDL and APOB as risk factors for heart disease.
“All other studies on people involved populations with metabolic dysfunction or individuals with innate Genetic causes From high LDL, “he told Fox News Digital.
The results seem to contradict what most clinicians would envision and what doctors are taught in medical training, Norwitz states.
“Although this data does not prove that conventional understanding is” wrong “, by themselves, they suggest that the conventional model has a big blind place.”
This is the first perspective trial of this kind in a unique population that is of traditional guidelines that are often referred to as “high risk,” said one doctor, asking important questions about how the cardiovascular risk is estimated in the context of a low -carbohydrate diet. (East)
According to Norwitz, a cardiac shooting, including Cac result, has “much more value” than Cholesterol levels In predicting the advancement of plaque.
“So the CAC results can be used to risk patients and help in individualization of care,” he told Fox News Digital.
Scher noted that “ketogenic therapy” can be effective in treating certain metabolic conditions, but some colors continue the keto diet because of its cholesterol.
“This study provides support that they do not necessarily stop a diet or treat their cholesterol – rather, they can work with their Health team For more individualized and more appropriate heart processing, “he advised.
Asking important questions
Dr. Ken Berry, a family doctor and Diabetes specialist He was not involved in the study in Tennessee, but shared his thoughts about what he described as a “revolutionary” study.
“The study did not determine the connection between LDL-C, APOB and the progression of the coronary plaque during one year using high-resolution CT angiography,” Fox News Digital said.
“Instead, the strongest predictor of the plaque progress was the already existing plaque, not the cholesterol levels-all the researchers conclude that” the plaque is a plaque, Apob no. “
The existing plaque level seemed to be a better predictor of a future plaque accumulation, although some experts warned that there were limitations. (East)
This is the first promising such trial in a unique population that has often marked ‘high risk to traditional guidelines,’ Berry said, asking important questions about how cardiovascular risk is estimated in a context with low carbohydrates, a high -fat diet.
“An obvious implication is that if a very high level APOB -A is not a good risk of risk of heart attack in this specific group of people, is it a good predictor in any group of people?” he said.
“Or is it, as I doubt, just the latest popular laboratory test used to scare people to eat properly human nutrition Rich in saturated fat? “
Potential study limit
Dr. Bradley Serwer, a cardiologist and the main doctor of Vitalsolution, a company based in Cincinnati offering cardiovascular and anesthesiology services to hospitals across the country, examined the study and pointed out some potential limitations.
“A limited scope of a study, which includes low -risk population, makes it challenging to generalize the findings of a wider, vulnerable population,” Serwer told Fox News Digital.
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“Although the aim of the study was to propose a hypothesis about the role of nutritional cholesterol, it does not provide final evidence for or against its importance.”
The cardiologist, however, agrees with the authors that “improved risk stratification tools” are key to identifying individuals with a higher risk of coronary artery disease.
The effects of ketogenic diet can be measured using a meter of ketosis. “I hope that doctors will accept this research and treat this specific population of people differently than other patients, understanding the unique physiological condition of ketosis and metabolic benefits it provides,” the researcher said. (East)
“As doctors, our main responsibility lies in the assessment of each patient on an individual basis and cooperation with them through a joint decisions on the development of the most appropriate long -term care plan,” he added.
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Michelle Routhenstein, a dietitian registered in New York, who specializes in heart disease, noted that plaque formation is a multi -stage process that can take years.
“The environment of the artery must be suitable for plaque creation,” said Routhenstein, who was not part of the study, for Fox News Digital.
“This is an extraordinary group of people showing extraordinary physiology.”
“For example, individuals with high blood pressureThe subgroup that was excluded from the study is more prone to the endothelial damage that causes Apob more easily deposited in the wall of the artery. “
“If one already has a plaque in the arteries and maintains elevated LDL -A apob levels, then it can develop in multiple plaques, as seen in this study.”
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“However, if someone is metabolic healthyNo plaques at the starting level, and increased the level of APOB and LDL, then the environment does not necessarily cause plaque formation during a one-year period. “
Routhenstein pointed to previous research showing that high LDL and APOB during the year of one’s life, usually in combination with inflammation, insulin resistance and/or oxidative stress, can increase the risk of plaque development.
“It is important to note that many people who implement the ketogenic diet and neglect the high levels of LDL -Ai Apob -and they usually do not know that they have a soft beer plaque,” said a nutritionist. (East)
“It is important to note that many people who implement the ketogenic diet and neglect the high levels of LDL -Ai Apob -a usually do not know they have a soft plaque for cooking,” she added.
“Therefore, their counseling to neglect the level of LDL -Ai APOB -A can be harmful -especially in a world where heart disease is so prevalent and remains a leading cause of death globally.”
Looking forward
Scher said he hoped more researchers would inspire Furthermore this study and apply it to a different population.
“But for now, I hope that doctors will accept this research and treat this specific population of people differently from other patients, understanding the unique physiological condition of ketosis and metabolic benefits it provides,” he said.
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In addition to multiple studies that assessed the risk in this population, Norwitz said that the team hoped to further explore the mechanisms of the phenotype of the hyper-recreation (LMHR).
“This is an extraordinary group of people showing extraordinary physiology,” he added.
