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GLP-1 receptor agonists (GLP-1 RAS), drugs that help in control Type 2 diabetes And obesity, can have a deep impact on physical wellness – but what about mental health?
Some examples of these drugs include semaglutides, such as Oskempic and Wegovy, and Liraglutide, such as Victose and Saxend.
Different studies pointed to GLP-1 RAS by causing Complications of mental healthlike anxiety and depression.
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National Health Institutes (NiH) published a study in June 2024, which considered the connection between semaglutide therapy and “exacerbation of mood disorders”.
The study emphasized the connection between negative mood swings in patients with type 2 diabetes The history of depressionWarning health service providers to be aware of this “potential risk”.
Studies discussed the connection between GLP-1 Ra drug and mood swings. (East)
But more recent studyPublished in Diabetes, obesity and metabolism, they suggested that these mood swings were associated with genetic variations of different populations and ancestors in the UK.
Although the GLP-1 Ra variants had “consistent cardiometabolic effects” in all groups, researchers said that negative impacts on mental health are “more diverse”, concluding that any changes in behavior “probably do not behave directly through through [the medications]. “
Doctors deal with medication and mood
Dr. Brett Osborn, a neurosurgeon in Florida, who often prescribes GLP-1 to his patients, believes that “there is no consistent causal” between these drugs and mental illnesses.
“Researchers questioned genetic markers in nearly half a million people from different backgrounds in search of a gene connection behind GLP-1 receptor and mental health problems like Depression, anxiety Or a suicide idea – and they didn’t find it, “he summed up.
GLP-1 receptor agonists are associated with mood swings, patients and doctors reported. (East)
People who obese Or the diabetes of type 2 “is often already depressed” without medication, the doctor pointed out.
“These conditions take a tribute – physically, emotionally and social,” he said. “So, yes, a large part of the patient who runs GLP-1 drugs are already dealing with fighting for mental health. But this is not because of the drug-it’s because of illness.”
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Once these individuals begin to lower weight, blood sugar is stabilized and energy improves, which usually raises their mood.
“GLP-1 drugs help people regain their health,” Osborn remarked. “They reduce inflammation. They lower the blood sugar. They Waist reduction. ”
“And when people look and feel better, when their bodies finally start working for them instead of against them, they often smile more, not less.”
“GLP-1 drugs help people regain their health,” one doctor said. “And when people look and feel better, when their bodies finally start working for them instead of against them, they often smile more, not less.” (East)
Dr. Muhammad Ghanem, a Bariatric surgeon At the Orlando Secondary Loss Institute and the Institute for Bariatric Surgery, they shared in a separate interview with Fox News Digital that, although some of his patients reported on mood swings, others “have that at all”.
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“Changes in depression or mood are very common regardless of that, especially today, and so hard [determine] Whether it is associated with GLP-1 agonist or it is a coincidental that they started suffering from them after they started that medicine, “he said.
“It’s really hard to say if this can happen to a personality change due to weight loss or it is a side effect due to a mood change,” he added. “I don’t think we have enough information yet to get to that conclusion.”
For those interested in GLP-1 RA or experience mood swings while taking them, an expert emphasized the importance of holding in close contact with medical providers. (East)
Patients who lose weight with GLP-1 Ras can feel a “great reinforcement” in confidence as well as a change in personality and Even relationshipsaccording to Ghanem.
“It really depends on the person and the support system they have,” he said. “You need appropriate, randomized controlled tests to reach a conclusion and better studies to determine if this is associated with the medication itself or just weight loss.”
“It is important for all doctors who prescribe these medicines to be aware and check the patient’s history.”
For those interested in these medicines or experience mood swings while taking them, the surgeon emphasized the importance of holding in close contact Medical providers.
“Like any other medicine, they can have potential side effects,” he said.
Ghanem recommended the search for professionals and practices that take a “holistic approach” to weight loss, offering support for mental health with medication.
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Dr. Brunilda Nazario, MD, editor -in -chief of doctors for medical questions on WebMD, told Fox News Digital that “obesity is complicated”.
“Obesity experts … They are cautiously excited how well these drugs work,” she said.
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“With current studies showing conflicting results on mood disorders and use of GLP-1 drugs, it is important that all doctors who prescribe these medicines are aware of and check the patient’s history before prescribing [them]. “
“Don’t be afraid to seek help if you think something is wrong – your health depends on it,” one expert suggested. (East)
Nazario emphasized that “vital” that the users of GLP-1 RA listen to their bodies, inviting them to pay attention to their feelings and know the symptoms of mood disorders.
“Don’t be afraid to seek help if you think something is wrong – Your health It depends on it, “he added.
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Nazario noted that GLP-1 Ras could affect mood in many different ways.
“Not everyone is negative – they also have the potential to improve the mood,” she said. “Just looking at great results can increase self -esteem, confidence and body image.”
